Most tests measure what a single organ is doing. Regulatory RNA reveals what the whole body is doing — because cells broadcast their state into the blood, and we've learned to read the broadcast.
When tissue is stressed — by an injury, a tumor, or any disease process — it creates a distinct microenvironment. The cells inside that environment release regulatory RNA molecules such as microRNA (miRNA) and small nucleolar RNA (snoRNA) as a form of intercellular communication.
A large share of these molecules travels packaged inside exosomes, tiny vesicles that carry the RNA into the surrounding tissue and, eventually, into peripheral blood. That means a single draw can hold molecular echoes of what's happening across the body — no biopsy of any one organ required.
Read enough of these signals together and a pattern emerges: a fingerprint of the underlying state. That fingerprint is what The VIBE's models are built to recognize.
In a military cohort, two conditions that look alike on the surface — mild traumatic brain injury and post-traumatic stress disorder — carry different molecular signatures in the blood. Our approach was able to distinguish between them.
That distinction matters. The two conditions overlap in symptoms but call for very different care, and until now telling them apart has been slow and imprecise.
Genomic and transcriptomic work has linked specific gene variants to injury severity and recovery — including inflammatory and neuronal genes such as IL1B, TNF, APOE, and BDNF. The APOE ε4 allele, for instance, tracks with poorer cognitive recovery.
Circulating microRNAs shift within hours of injury. Altered miR-21, miR-92a, and miR-425 reflect neuronal stress and neuroinflammation, and emerging miRNA panels report accuracy above 0.90 AUC when separating TBI patients from healthy controls.
Paraphrased from the peer-reviewed literature on TBI biomarkers (SNPs, gene expression, and regulatory RNA). Full citations available on request.
Because blood pools signals from across the body, a single sample gives a holistic read rather than a view of one isolated organ.
No surgical biopsy, no scan required. A routine draw makes deep molecular testing something you can repeat over time.
Repeatable sampling turns a one-time result into a longitudinal signal — the raw material for prediction, not just detection.
A great deal of clinically meaningful biomarker research never reaches patients — the findings exist, but nobody has turned them into working predictive tools.
The VIBE is built to close that gap. Supervised models learn from labeled outcomes; unsupervised models surface structure no one labeled in advance. As our LLM layer continuously reads new peer-reviewed literature alongside the biomarkers we collect, associations that were stranded in journals become analytics you can actually use.
The more streams feed the model — genetic, clinical, wearable, nutritional — the more of these buried relationships it can find. That's the whole point of vertical integration: scale and breadth of data that, correlated together, has never been assembled at this level before.
The Ultimate panel includes our regulatory-RNA liquid biopsy. Join early access to be among the first to run it.